Biography

Jiachen-Liu is a diligent researcher with extensive multi-/inter-disciplinary expertise in biostatistics and bioinformatics, big data, genetics, transcriptomics, epigenomics, proteomics, complex traits and diseases (especially osteoarthritis, sarcopenia, and obesity), metabolomics and metagenomics.

Liu’s work is published in 22 peer-reviewed publications including journals such as Redox Biology, Molecular Cancer, Ageing Research Reviews, Journal of Translational Medicine, Human Genetics and Therapeutic Advances in Neurological Disorder. As of April 2024, these publications have been cited more than 883 times and his H-index is 14 since the first article published in 2020. Liu currently serves on the editorship/ed-itorial boards of journals(e.g.,iMeta), who also worked as a reviewer in several SCI journals such as Age and Ageing, Obesity Reviews, International Journal of Surgery, Diabetes, Obesity and Metabolism, and Molecular Neurobiology.

Liu’s primary research interests include all those areas that are related to addressing the question: What and how gene expression network and environmental factors incur higher risk of, or better protection against, complex diseases, such as sarcopenia and osteoarthritis.

Liu is also interested in generating, analyzing and integrating big data of various omics in vivo in humans. The purpose is to elucidate the impact of gene expression/regulation and protein expression/modification on the disease course in the form of functional networks/modules/pathways and how the knowledge gained on these molecular mechanisms in humans would translate into better prediction/intervention/precision medicine and drug development.

Interests
  • Multi-omics
  • Genetics
  • Transcriptomics
  • Microbiome
  • Drug repositioning
  • Obesity
  • Osteoarthritis
  • Sarcopenia
Education
  • Medical doctor (eight-year program), 2017

    Central south university

  • Visiting Scholar, 2023

    Washington University in St. Louis

Recent Publications

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(2023). WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury.

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(2023). Minimally invasive approaches for the early detection of endometrial cancer.

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(2023). Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders. Neurobiology of Disease.

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(2023). Uncovering the gene regulatory network of type 2 diabetes through multi-omic data integration.

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(2022). Ferroptosis, a Regulated Neuronal Cell Death Type After Intracerebral Hemorrhage. Front Cell Neurosci.

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(2022). Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte. Biomed Pharmacother.

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(2022). Multi-omics research in sarcopenia: Current progress and future prospects. Ageing Res Rev.

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(2022). Clearance Systems in the Brain, From Structure to Function. Front Cell Neurosci.

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(2021). Blood Immune Cell Composition Associated with Obesity and Drug Repositioning Revealed by Epigenetic and Transcriptomic Conjoint Analysis. Front Pharmacol.

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(2021). The Role of Exosomes and Their Cargos in the Mechanism, Diagnosis, and Treatment of Atrial Fibrillation. Front Cardiovasc Med.

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(2021). Ligustrazine Alleviate Acute Lung Injury Through Suppressing Pyroptosis and Apoptosis of Alveolar Macrophages. Front Pharmacol.

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(2021). Microglia: A Double-Edged Sword in Intracerebral Hemorrhage From Basic Mechanisms to Clinical Research. Front Immunol.

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(2021). The value of miRNAs in the prognosis of obese patients receiving bariatric surgery. Am J Transl Res.

(2021). Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics. Pharmaceutics.

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(2020). LILRB4, from the immune system to the disease target. Am J Transl Res.

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(2020). Interaction of Microglia and Astrocytes in the Neurovascular Unit. Front Immunol.

PDF Cite DOI

(2020). Long-term outcomes of monascin - a novel dual peroxisome proliferator-activated receptor γ/nuclear factor-erythroid 2 related factor-2 agonist in experimental intracerebral hemorrhage. Ther Adv Neurol Disord.

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