Jiachen-Liu is a diligent researcher with extensive multi-/inter-disciplinary expertise in biostatistics and bioinformatics, big data, genetics, transcriptomics, epigenomics, proteomics, complex traits and diseases (especially osteoarthritis, sarcopenia, and obesity), metabolomics and metagenomics.

Liu’s work is published in 22 peer-reviewed publications including journals such as Redox Biology, Molecular Cancer, Ageing Research Reviews, Journal of Translational Medicine, Human Genetics and Therapeutic Advances in Neurological Disorder. As of Jan 2025, these publications have been cited more than 920 times and his H-index is 15 since the first article published in 2020. Liu currently serves on the editorship/ed-itorial boards of journals(e.g.,iMeta) and has reviewed over 80 manuscripts across more than 25 SCI journals, including Obesity Reviews, International Journal of Surgery, Diabetes, Obesity and Metabolism, and Molecular Neurobiology.

Liu’s primary research interests include all those areas that are related to addressing the question: What and how gene expression network and environmental factors incur higher risk of, or better protection against, complex diseases, such as sarcopenia and osteoarthritis.

Liu is also interested in generating, analyzing and integrating big data of various omics in vivo in humans. The purpose is to elucidate the impact of gene expression/regulation and protein expression/modification on the disease course in the form of functional networks/modules/pathways and how the knowledge gained on these molecular mechanisms in humans would translate into better prediction/intervention/precision medicine and drug development.