Jiachen-Liu is a diligent researcher with extensive multi-/inter-disciplinary expertise in biostatistics and bioinformatics, big data, genetics, transcriptomics, epigenomics, proteomics, complex traits and diseases (especially osteoarthritis, sarcopenia, and obesity), metabolomics and metagenomics.

Liu’s work is published in 40 peer-reviewed publications including journals such as Briefings in Bioinformatics, International Journal of Surgery, MedComm, Redox Biology, Molecular Cancer, and Ageing Research Reviews. As of Nov 2025, these publications have been cited more than 1800 times and his H-index is 18 since the first article published in 2020. Liu currently serves on the editorship/ed-itorial boards of journals(e.g.,iMeta) and has reviewed over 200 manuscripts across more than 50 SCI journals, including Age and Ageing, Environmental Research, Obesity Reviews, International Journal of Surgery, Diabetes, Obesity and Metabolism, and Research.

Liu’s primary research interests include all those areas that are related to addressing the question: What and how gene expression network and environmental factors incur higher risk of, or better protection against, complex diseases, such as sarcopenia and osteoarthritis.

Liu is also interested in generating, analyzing and integrating big data of various omics in vivo in humans. The purpose is to elucidate the impact of gene expression/regulation and protein expression/modification on the disease course in the form of functional networks/modules/pathways and how the knowledge gained on these molecular mechanisms in humans would translate into better prediction/intervention/precision medicine and drug development.